Spiro[1,3-benzodioxole-2,4′(4H-3,1)-benzothiazines and their cleavage with amines and hydrazines. A new series of spiranes.
✍ Scribed by N. Latif; I.F. Zeid; N. Mishriky; F.M. Assad
- Book ID
- 104234817
- Publisher
- Elsevier Science
- Year
- 1974
- Tongue
- French
- Weight
- 93 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0040-4039
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## Treatment of the hydrochloride salts of 4-chloro-5-(2halomethylaryl-imino)-5H-l,2,3-dithiazoles (2) with sodium cyanoborohydride in THF at room temperature gave 2-cyan0-4H-3,l -benzothiazines ( I ) in good to moderate yields. 2-Cyano-4H-3,l -benzoxazines (4) were obtained in good to moderate yiel
## Abstract New compounds of 2‐aryl‐4__H__‐3,1‐benzothiazine set were synthesized and tested for their antiproliferative activity as part of our research in the antitumor field. The title compounds were obtained by the reaction of aryl‐modified sulfinylbis((2,4‐dihydroxyphenyl)methanethione) with 2