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Spiro-piperidine non-peptide neurokinin-1 receptor antagonists

โœ Scribed by D.R. Armour; S.P. Watson; N.A. Pegg; N.M. Heron; D. Middlemiss; C. Chan; T.J. Cholerton; T. Hubbard; M.V. Vinader; H.G. Davies; J.D. Cocker; D.E. Bays; P. Ward

Book ID
108038919
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
251 KB
Volume
5
Category
Article
ISSN
0960-894X

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Spiro-Substituted Piperidines as Neurokinin Receptor Antagonists. Part 3. Synthesis of (ยฑ)-N-[2-(3,4-Dichlorophenyl)-4-(spiro-substituted piperidin-1'-yl)butyl]-N-methylbenzamides and Evaluation of NK 1 -NK 2 Dual Antagonistic Activities. -In order to obtain more potent NK 1 -NK 2 dual antagonists a