𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Spiral coronary angiography using a blood pool agent

✍ Scribed by Steffen Ringgaard; Michael Pedersen; Jonas Rickers; Lars O. Johansson; Peter Börnert; Erik M. Pedersen

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
304 KB
Volume
22
Category
Article
ISSN
1053-1807

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Purpose

To experimentally investigate the optimum dose of an iron‐oxide‐based blood pool agent for spiral coronary MR angiography (MRA), and the difference between single and multiple spiral excitations in each cardiac cycle.

Materials and Methods

Images using single and triple spiral excitations in each cardiac cycle were obtained in late diastole of the left main coronary artery in eight pigs following an inversion prepulse. Measurements were obtained before and after injection of increasing doses of an iron oxide blood pool agent (Clariscan) corresponding to concentrations of 0.8, 2.2, and 3.9 mg Fe/kg BW. The signal‐to‐noise ratio (SNR) and contrast‐to‐noise ratio (CNR) were measured.

Results

For 0.8 mg Fe/kg BW relative to precontrast values, a significant increase was observed for both one (SNR: 2.3, CNR: 3.8) and three (SNR: 1.4, CNR: 2.2) excitations (P < 0.01). When the dose was increased from 0.8 mg Fe/kg BW to 2.2 mg Fe/kg BW, only the SNR (P < 0.01) increased further. Significantly higher CNR (1.6–1.8) and SNR (1.4–1.6) values were seen for one excitation relative to three excitations at all concentrations (P < 0.05).

Conclusion

At low concentrations, an iron oxide blood pool agent can increase SNR and CNR significantly with both single excitation and triple excitations using an inversion‐prepared spiral acquisition scheme. At higher concentrations, T2* effects reduce image quality. J. Magn. Reson. Imaging 2005;22:213–218. © 2005 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Blood pool agent strongly improves 3D ma
Blood pool agent strongly improves 3D magnetic resonance coronary angiography using an inversion pre-pulse
✍ Mark B. M. Hofman; Robert E. Henson; Sándor J. Kovács; Stefan E. Fischer; Randal 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 187 KB

The ability of a blood pool contrast agent to enhance MR coronary angiography was defined. The proximal coronary vessels of pigs were imaged before and after administration of Gd-DTPA bound covalently to bovine serum albumin (0.2 mmol/ kg). The contrast agent resulted in a reduction of the blood T 1

Optimization of a blood pool contrast ag
Optimization of a blood pool contrast agent injection protocol for MR angiography
✍ Philippe Robert; Xavier Violas; Robin Santus; Denis Le Bihan; Claire Corot 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 256 KB

## Abstract ## Purpose To design an ideal first‐pass profile for MR angiography (MRA) by optimizing a multiphasic injection protocol based on two experimental animal models. ## Materials and Methods An equivalent contrast‐enhanced (CE) MRA injection protocol was developed with controlled injecti

Coronary MR angiography using citrate-co
Coronary MR angiography using citrate-coated very small superparamagnetic iron oxide particles as blood-pool contrast agent: Initial experience in humans
✍ Moritz Wagner; Susanne Wagner; Jörg Schnorr; Eyk Schellenberger; Dietmar Kivelit 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 256 KB

## Abstract ## Purpose: To evaluate very small superparamagnetic iron oxide particles (VSOP‐C184) as blood‐pool contrast agent for coronary MR angiography (CMRA) in humans. ## Materials and Methods: Six healthy volunteers and 14 patients with suspected coronary artery disease underwent CMRA afte

First-pass contrast-enhanced magnetic re
First-pass contrast-enhanced magnetic resonance angiography in humans using ferumoxytol, a novel ultrasmall superparamagnetic iron oxide (USPIO)-based blood pool agent
✍ Wei Li; Sean Tutton; Anthony T. Vu; Linda Pierchala; Belinda S.Y. Li; Jerome M. 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 486 KB

## Abstract ## Purpose To evaluate the feasibility of first‐pass contrast‐enhanced magnetic resonance angiography (MRA) using ferumoxytol in humans. ## Materials and Methods First‐pass and equilibrium phase MRA were performed using ferumoxytol in one healthy volunteer and 11 patients with a fast

Combined use of the intravascular blood-
Combined use of the intravascular blood-pool agent, gadomer, and carbon dioxide: A novel type of double-contrast magnetic resonance angiography (MRA)
✍ Robbert M. Maes; Jonathan S. Lewin; Jeffrey L. Duerk; Frank K. Wacker 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 487 KB

## Abstract ## Purpose To evaluate the combined use of carbon dioxide (CO~2~) and a gadolinium‐based blood‐pool agent for magnetic resonance angiography (MRA). ## Materials and Methods After an initial intravenous injection of the blood‐pool agent Gadomer (Schering AG, Germany), repeated transca