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Optimization of a blood pool contrast agent injection protocol for MR angiography

✍ Scribed by Philippe Robert; Xavier Violas; Robin Santus; Denis Le Bihan; Claire Corot

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
256 KB
Volume
21
Category
Article
ISSN
1053-1807

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✦ Synopsis

Abstract

Purpose

To design an ideal first‐pass profile for MR angiography (MRA) by optimizing a multiphasic injection protocol based on two experimental animal models.

Materials and Methods

An equivalent contrast‐enhanced (CE) MRA injection protocol was developed with controlled injection modalities (injection rate, volume, and dose) in rabbits and pigs. P792, a blood pool contrast agent, was injected in 17 male New Zealand rabbits and five farm pigs with variable injection schemes (mono‐ and multiphasic). From the gadolinium (Gd) blood concentration data, a simulation of an MR acquisition was performed to evaluate the impact of such an injection protocol on MR arterial signal and to select the best injection protocol.

Results

An empirical relationship between the arterial peak concentration and the injection parameters was found in the rabbits and pigs, allowing precise prediction of the first‐pass profile. Of the four injection scheme strategies tested (standard bolus and bi‐, tri‐, and multiphasic injection protocols), the multiphasic “ramp” injection protocol provided the most optimal contrast agent pharmacokinetics with a durable plateau of concentration.

Conclusion

Ramp injection protocol provides an optimized first‐pass profile for CE‐MRA. J. Magn. Reson. Imaging 2005;21:611–619. © 2005 Wiley‐Liss, Inc.

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