✍ Scribed by Yoshiki Kaneoke; Masahiro Furuse; Suguru Inao; Katsuyoshi Saso; Kazuo Yoshida; Yoshimasa Motegi; Motomu Mizuno; Akira Izawa
No coin nor oath required. For personal study only.
Measurements were made of T1 of bound water (T1b) and bound water fraction (alpha) for gelatin solutions and human tissues (sera, brain tumor, cerebral white matter). Bound water fraction in each sample was measured by means of thermal analysis (differential scanning calorimetry: DSC). T1 values were measured by FONAR QED 80-alpha. T1b values were calculated by an equation derived from the fast-exchange two-state model. In the study of gelatin solutions, the relationship between T1 and water content differed depending on the sort of solutions. This was considered to be due to differences in T1b values. In each biological tissue the values of T1b and alpha had different distributions. These results indicate that values of T1b and alpha for biological tissues may be altered in correspondence to the changes in pathophysiological states in those tissues.
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## Abstract __T__~1~ and __T__~2~ can be rapidly determined with a combination of multiangle spoiled gradient recalled echo (SPGR) and steady‐state free precession (SSFP) imaging. Previously, we demonstrated a simple method for determining the set of SPGR and SSFP angles that provided greater __T__