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Determination of optimal angles for variable nutation proton magnetic spin-lattice, T1, and spin-spin, T2, relaxation times measurement

✍ Scribed by Sean C.L. Deoni; Terry M. Peters; Brian K. Rutt

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 204 KB
Volume: 51
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.10661

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✦ Synopsis

Abstract

T~1~ and T~2~ can be rapidly determined with a combination of multiangle spoiled gradient recalled echo (SPGR) and steady‐state free precession (SSFP) imaging. Previously, we demonstrated a simple method for determining the set of SPGR and SSFP angles that provided greater T~1~ and T~2~ precision than a set of uniformly spaced angles. In this article a more rigorous approach for determining angles is described. Weighted least‐squares is also introduced for T~1~ and T~2~ estimation and a novel weighting function described. This new approach, suited for imaging applications where large T~1~ and T~2~ ranges are anticipated, provides high and uniform precision over a wide range of T~1~ and T~2~ values. Magn Reson Med 51:194–199, 2004. © 2003 Wiley‐Liss, Inc.

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