Spin-lattice relaxation in murine tumors after in vivo treatment with interferon α/β or tumor necrosis factor α

✍ Scribed by M. A. Macrì; C. Casieri; F. de Luca; B. Maraviglia; F. Belardelli; E. Proietti; G. Carpinelli; F. Podo

• Book ID: 102952411
• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 507 KB
• Volume: 23
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.1910230103

✦ Synopsis

Abstract

^1^H NMR spin–lattice relaxation times (T^1^) were measured in vitro and in vivo in Friend leukemia cell tumors during subcutaneous tumor growth in syngeneic mice and after in vivo administration of either purified murine interferon α/β (IFN) or recombinant tumor necrosis factor α (TNF). Untreated tumors exhibited monoexponential T^1^ relaxation independently of tumor age at least until Day 16 after implantation. Histological examinations showed that under these conditions tumors were highly homogeneous and substantially free of necrotic areas. Peritumoral administrations of either IFN or TNF did not significantly alter the tumor relaxation properties at early stages of inhibition of tumor growth. The longitudinal relaxation decay became instead clearly biexponential at later stages (more than 7 days of IFN treatment or 2 days after TNF administration). While the T^1^ relaxation behavior could be unequivocally correlated with the presence of necrotic areas in these tumors, it could not be considered as an early marker of the altered growth capability, induced by administration of either IFN or TNF. © 1992 Academic Press, Inc.