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Sphingosine-1–Phosphate, FTY720, and Sphingosine-1–Phosphate Receptors in the Pathobiology of Acute Lung Injury

✍ Scribed by Natarajan, Viswanathan; Dudek, Steven M.; Jacobson, Jeffrey R.; Moreno-Vinasco, Liliana; Huang, Long Shuang; Abassi, Taimur; Mathew, Biji; Zhao, Yutong; Wang, Lichun; Bittman, Robert; Weichselbaum, Ralph; Berdyshev, Evgeny; Garcia, Joe G. N.

Book ID
125461539
Publisher
American Thoracic Society
Year
2013
Tongue
English
Weight
851 KB
Volume
49
Category
Article
ISSN
1044-1549

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## Abstract FTY720, a sphingosine 1‐phosphate (S1P) analog, acts as an immunosuppressant through trapping of T cells in secondary lymphoid tissues. FTY720 was also shown to prevent tumor growth and to inhibit vascular permeability. The MTT proliferation assay illustrated that endothelial cells are