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Lung Tumor Development in the Presence of Sphingosine 1-phosphate Agonist FTY720

✍ Scribed by Natália R. Salinas; Camila T. Lopes; Patrícia V. Palma; Celina T. Oshima; Valquiria Bueno

Book ID
107636315
Publisher
Springer Netherlands
Year
2009
Tongue
English
Weight
197 KB
Volume
15
Category
Article
ISSN
1219-4956

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## Abstract FTY720, a sphingosine 1‐phosphate (S1P) analog, acts as an immunosuppressant through trapping of T cells in secondary lymphoid tissues. FTY720 was also shown to prevent tumor growth and to inhibit vascular permeability. The MTT proliferation assay illustrated that endothelial cells are