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Sphingosine-1-phosphate stimulates human Caco-2 intestinal epithelial proliferation via p38 activation and activates ERK by an independent mechanism

โœ Scribed by Vijayalakshmi Thamilselvan; Wei Li; Bauer E. Sumpio; Marc D. Basson


Book ID
115044832
Publisher
Society for In Vitro Biology
Year
2002
Tongue
English
Weight
869 KB
Volume
38
Category
Article
ISSN
1475-2689

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## Abstract We have shown that the bacterial iron chelator, deferoxamine (DFO), triggers inflammatory signals including the production of CXC chemokine ILโ€8, in human intestinal epithelial cells (IECs) by activating the ERK1/2 and p38 kinase pathways. In this study we investigated the mechanisms in