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Sphingosine-1-phosphate regulates RGS2 and RGS16 mRNA expression in vascular smooth muscle cells

✍ Scribed by Mariëlle C. Hendriks-Balk; Najat Hajji; Pieter B. van Loenen; Martin C. Michel; Stephan L.M. Peters; Astrid E. Alewijnse

Book ID: 113588081
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 419 KB
Volume: 606
Category: Article
ISSN: 0014-2999
DOI: 10.1016/j.ejphar.2009.01.018

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## Abstract Sphingosine 1‐phosphate (S1P) has been shown to regulate smooth muscle cell proliferation, migration, and vascular maturation. S1P increases the expression of several proteins including COX‐2 in vascular smooth muscle cells (VSMCs) and contributes to arteriosclerosis. However, the mecha