Sphingosine-1-phosphate promotes mouse melanocyte survival via ERK and Akt activation
β Scribed by Dong-Seok Kim; Eui-Soo Hwang; Jai-Eun Lee; Sook-Young Kim; Kyoung-Chan Park
- Book ID
- 114283827
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 401 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0898-6568
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## Abstract Sphingosine 1βphosphate (S1P) has been shown to regulate expression of several genes in vascular smooth muscle cells (VSMCs) and contributes to arteriosclerosis. However, the mechanisms regulating epidermal growth factor receptor (EGFR) expression by S1P in aortic VSMCs remain unclear.
Several studies have argued that G-protein-coupled receptors (GPCR) have the capacity to promote activation of receptor tyrosine kinases. The current studies were performed to examine the regulation of the extracellular regulated kinase (ERK)1/2 and AKT pathways by conjugated and unconjugated bile a