Spherical agglomerates of water-insoluble drugs
β Scribed by Roland Bodmeier; Ornlaksana Paeratakul
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 901 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0022-3549
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This study reports the results of the combined effect of pH and surfactant on the dissolution of piroxicam (PX), an ionizable water-insoluble drug in physiological pH. The intrinsic dissolution rate (J total ) of PX was measured in the pH range from 4.0 to 7.8 with 0%, 0.5%, and 2.0% sodium lauryl s
The purpose of this work is to propose a new, useful, and easy chromatographic method to determine accurately the aqueous dissociation constant of drugs sparingly soluble in water. The method uses the rigorous intersolvental pH scale, (w)(s)pH, i.e., the pH measurements are made in the mobile phase