The purpose of this work is to propose a new, useful, and easy chromatographic method to determine accurately the aqueous dissociation constant of drugs sparingly soluble in water. The method uses the rigorous intersolvental pH scale, (w)(s)pH, i.e., the pH measurements are made in the mobile phase
Chromatographic determination of aqueous dissociation constants of some water-insoluble nonsteroidal antiinflammatory drugs
✍ Scribed by Oumada, Fadoua Z. (author);Raand̀fols, Clara (author);Roseand́s, Martiand́ (author);Bosch, Elisabeth (author)
- Publisher
- John Wiley and Sons Inc.
- Year
- 2002
- Tongue
- English
- Weight
- 140 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0022-3549
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## Abstract An analytical method for the determination of trace levels of six different nonsteroidal antiinflammatory drugs (NSAIDs) in water samples has been developed and validated. Environmentally relevant pharmaceuticals were chosen according to human consumption in Poland. Final analysis of th
The compression of water-insoluble drug monolayers spread on the aqueous subphase containing cyclodextrins (CD) led to a shift of surface pressure (pi)-area (A) isotherms toward smaller molecular areas with respect to the pi-A isotherms on the pure water subphase. The displacement of the compression