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Spermidine level as a parameter in the treatment of patients with malignant melanoma

✍ Scribed by J. M. Smit; H. Jurjens; J. Bouman; J. Bijzet; D. Th. Sleijfer; M. G. Woldring; N. H. Mulder

Publisher: Springer
Year: 1985
Tongue: English
Weight: 228 KB
Volume: 10-10
Category: Article
ISSN: 0340-6997
DOI: 10.1007/bf00254474

No coin nor oath required. For personal study only.

✦ Synopsis

Before, during, and after 19 courses of chemotherapy given to patients with disseminated malignant melanoma plasma spermidine levels were determined with a radioimmunoassay. Baseline values were normal in 17 courses, a doubling of plasma levels following chemotherapy occurred in 13 courses. There was no relation between the occurrence of a tumor response and an increase in spermidine levels nor between hematological toxicity or digestive tract toxicity and spermidine levels.

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