Spectroscopy of Isolated Gramicidin Peptides

✍ Scribed by Ali Abo-Riziq; Bridgit O. Crews; Michael P. Callahan; Louis Grace; Mattanjah S. de Vries

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 205 KB
• Volume: 45
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.200601516

✦ Synopsis

Many details of intrinsic properties of biomolecules are masked by elements of the biological environment, such as the solvent and intermolecular interactions. Separation of the inter-and intramolecular aspects of biomolecular function requires the study of isolated molecules under solvent-free conditions or with a controlled and limited number of solvent molecules. This can be achieved by gas-phase spectroscopy; however, this approach has been limited to small molecules with masses below a few hundred amu. In 1985 Rizzo et al. reported the first molecular beam experiments with tryptophan [1,2] followed by work on di-and tri-amino acids. [3][4][5] Ever since, the hope to extend this technique to larger molecules has met with very little success. Although electrospray and [