Spectroscopic Studies and Crystal Structure of 4-(2-Hydroxy-3-Methoxybenzylideneamino)-N-(5-Methylisoxazol-3-yl) Benzenesulfonamide
✍ Scribed by Mustafa Yıldız; Hüseyin Ünver; Diğdem Erdener; Nazan Ocak İskeleli
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 336 KB
- Volume
- 40
- Category
- Article
- ISSN
- 1572-8854
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## Abstract The excitatory, amino acid ±2‐amino‐3‐(3‐hydroxy‐5‐methylisoxazol‐4‐yl)propionic acid hydrobromide was prepared in gram quantities in an 3.3% overall yield from methylbut 2‐ynoate. The key step was the facile preparation of methyl 3‐bromo‐5‐methylisoxazole‐4‐carboxylate.
RS)-2-Amino-2-(3-hydroxy-5-methylisoxazol-4-yl)acetic acid (AMAA) is a potent and selective agonist at the NMDA subgroup of excitatory amino acid receptors. To probe its interaction with these receptors we have developed a synthesis of [3H]AMAA. Bromination of a protected form of AMAA with NBS follo