✦ LIBER ✦

Spectroscopic, morphologic, and cytotoxic studies on major fractions of hematoporphyrin derivative and Photofrin II

✍ Scribed by Chung-Ho Sun; Eran Duzman; John Mellott; L.-H. Liaw; Dr. Michael W. Berns

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 858 KB
Volume: 7
Category: Article
ISSN: 0196-8092
DOI: 10.1002/lsm.1900070207

No coin nor oath required. For personal study only.

✦ Synopsis

This study characterizes the special properties of hematoporphyrin derivative (HpD) (Photofrin I) and Photofrin I1 with respect to the absorption and fluorescence spectra of the subfractions of the compounds in both solution and cells. In addition, data are presented demonstrating variation in the spectral amplitudes with respect to the age (shelf-life) of the commercially available compounds. Data are also presented confirming that fraction I11 is the active ingredient-containing fraction with respect to photosensitivity. The morphologic and electron microscopic analyses demonstrate that the first visible effect on cells following porphyrin sensitization can be detected within 1 minute of low level light exposure (10 J/cm2, 630 nm). The initial sites of morphologic damage are the mitochondria.

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