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Spectrophotometric method for the determination of a bifunctional DTPA ligand in DTPA-monoclonal antibody conjugates

✍ Scribed by Pippin, C. Greg; Parker, Tammy A.; McMurry, Thomas J.; Brechbiel, Martin W.


Book ID
121477289
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
445 KB
Volume
3
Category
Article
ISSN
1043-1802

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The bicyclic anhydride of DTPA-1-14C (BADTPA-1-14C) was synthesized and reacted with an antibody to human melanoma associated antigen (MAA) and with one to human class II major histocompatibility complex antigen (HLA-DR). DTPA-1-C incorporation per mole of anti MAA at molar ratios of 1:1 to 200:1 ra