Spectrophotometric determination of diphenhydramine hydrocholoride in an antiallergic cream

✍ Scribed by Fabrizio De Fabrizio

• Publisher: John Wiley and Sons
• Year: 1970
• Tongue: English
• Weight: 232 KB
• Volume: 59
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600591021

✦ Synopsis

In the case of dyes, enhanced adsorption is desirable for uniform coloring of solid dosage forms. However, in the case of drugs, adsorption to a seemingly inert excipient such as starch may affect their release and availability. Problems due to drug adsorption by excipients may also arise during in aitro evaluation of the solid dosage forms and during quantitative analysis for the active ingredient. This would be particularly true for potent drugs that have low effective doses. Adsorption studies during the preformulation stages in the development of a drug product can provide clues to such problems.