Spectral Fitting of NMR Spectra Using an Alternating Optimization Method with a Priori Knowledge

Improved quantification of in vivo1H NMR

Improved quantification of in vivo1H NMR spectra by optimization of signal acquisition and processing and by incorporation of prior knowledge into the spectral fitting

✍ A. A. De Graaf; W. M. M. J. Bovée 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 851 KB

## Abstract Quantification of localized __in vivo__ brain ^1^H spectra is in general very difficult due to excessive spectral overlap. In addition, intensity distortions may result from the effects of the NMR pulse sequence on the spins. This paper describes an approach to solving these problems. I