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Specificity of rat T cell receptor Vβ chain usage in proliferative responses to staphylococcal enterotoxin B

✍ Scribed by Karen S. Sellins; Donald Bellgrau; Daniel P. Gold

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
413 KB
Volume
22
Category
Article
ISSN
0014-2980

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✦ Synopsis

Specificity of rat T cell receptor V p chain usage in proliferative responses to staphylococcal enterotoxin B*

The staphylococcal enterotoxins (SE) are potent stimulators of T cell proliferative responses in humans and in mice. In these systems, the toxins function as superantigens and stimulate T cells bearing particular Vp. Although homology between the Vp of mice and humans is limited, related Vp families may respond to certain SE in a similar fashion. In this report,we have characterized the rat T cell response to staphylococcal enterotoxin B (SEB). Rat T cells from several lymphoid organs proliferated strongly in response to both commercially available and recombinant SEB. Using a polymerase chain reaction assay, we identified the predominant Vp families stimulated by this enterotoxin. The T cell receptor Vp elements used by rat T cells were similar to but not completely identical with those used by mice. TheVp profile stimulated depended on the purity of the SEB preparation used.

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