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Specificity in enzyme inhibition. 3. Synthesis of 5-substituted-2,2-dimethyl-4-imidazolidinones as inhibitors of tyrosine decarboxylase and histidine decarboxylase

✍ Scribed by Smissman, Edward E.; Inloes, Roger L.; El-Antably, Samir; Shaffer, Phyllis J.


Book ID
111933108
Publisher
American Chemical Society
Year
1976
Tongue
English
Weight
420 KB
Volume
19
Category
Article
ISSN
0022-2623

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ATP-Citrate Lyase as a Target for Hypolipidemic Intervention. Part 2. Synthesis and Evaluation of (3R\*,5S\*)-Ο‰-Substituted-3carboxy-3,5-dihydroxyalkanoic Acids and Their Ξ³-Lactone Prodrugs as Inhibitors of the Enzyme in vitro and in vivo. -A series of the title compounds is synthesized and evalua