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Specificities in natural cell-mediated cytotoxicity against lymphoblastoid cell lines I. Selective inhibition by cross-competition

✍ Scribed by Y. Koide; M. Takasugi

Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
537 KB
Volume
8
Category
Article
ISSN
0014-2980

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✦ Synopsis

Abstract

The apparent nonselective effects of natural cell‐mediated cytotoxicity tested directly on different lymphoblastoid cell targets were found to be quite specific in the cross‐competition assay. The specificity was detected through inhibition of cytotoxicity by competitor cells sharing common specificities with the target cells. Cross‐competition tests were performed employing eight lymphoblastoid lines including four T and four B cells. Selective inhibition observed between lymphoblastoid cell lines indicated that T and B cell lines were more antigenically similar within each group than between them. The target antigens that distinguish T cell from B cell lines have been tentatively called TA‐T and TA‐B.

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