Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease
β Scribed by Jean C. Augustinack; Anja Schneider; Eva-Maria Mandelkow; Bradley T. Hyman
- Publisher
- Springer-Verlag
- Year
- 2001
- Tongue
- English
- Weight
- 215 KB
- Volume
- 103
- Category
- Article
- ISSN
- 0001-6322
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Phospho-and unphospho-peptides were used to define the essential sequence for a tau epitope, which is recognized by Tau-1 antibody and phosphorylated in Alzheimer's disease (AD). The epitope was mapped within the amino acid residues 192-199 of tau and was phosphorylated by the p34cdc2/p58cyc'i" A pr
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