𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Specific reversal of cytolytic T lymphocyte - target cell interaction

✍ Scribed by Balk, Steven P. ;Mescher, Matthew F.

Publisher
Wiley (John Wiley & Sons)
Year
1981
Tongue
English
Weight
548 KB
Volume
16
Category
Article
ISSN
0275-3723

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✦ Synopsis

Abstract

A functional assay is described that measures the reversal of specific cytolytic T cell (CTL)‐target cell binding. Binding of ^51^Cr‐labeled P815 cells was stable in suspension but could be readily reversed by the addition of unlabeled P815 cells. The reversal of CTL‐tumor cell and CTL‐spleen cell binding was H‐2 specific; only cells of the same H‐2 type as the bound target cell could induce reversal. In all cases, tumor cells were substantially more efficient than spleen cells in inducing specific reversal.

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