Antibody-conjugated MHC class I tetramer
Antibody-conjugated MHC class I tetramers can target tumor cells for specific lysis by T lymphocytes
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Bruno Robert; Philippe Guillaume; Immanuel Luescher; Pedro Romero; Jean-Pierre M
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Article
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2000
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John Wiley and Sons
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English
β 114 KB
π 1 views
To demonstrate that antibody-guided targeting of antigenic MHC class I-peptide tetramer on tumor cells can render them susceptible to lysis by relevant cytotoxic T lymphocytes (CTL), biotinylated HLA-A\*0201/Flu matrix peptide complexes were tetramerized on streptavidin molecules previously coupled