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Specific regulation of immediate early genes by patterned neuronal activity

✍ Scribed by Dr. H. Z. Sheng; R. D. Fields; P. G. Nelson

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
821 KB
Volume
35
Category
Article
ISSN
0360-4012

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✦ Synopsis

Abstract

Electrical activity shapes development of the nervous system, presumably in part by regulating gene expression. A set of regulatory genes, immediate early genes (IEGs), which are responsive to a number of extrinsic cellular stimuli have been proposed to play a role in coupling such activity to gene expression. Using a semiquantitative polymerase chain reaction assay, we show that in dissociated mouse dorsal root ganglion neurons the expression of two IEGs, c‐fos and nur/77, is differentially sensitive to patterns of electrical stimulation. Differences in c‐fos activation did not correlate with the peak intracellular calcium [Ca^++^]i produced by the different stimulation patterns or with residual [Ca^++^]i following stimulation. However, the net increase in [Ca^++^]i (calcium time integral) was greater for the pulsed stimulus that activated c‐fos (6 impulses/min), compared to the ineffective stimulus (12 impulses/2 min). This system of genes seems suited to mediating the coupling between electrical activity and other functional genes. © 1993 Wiley‐Liss, Inc.

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