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Specific recognition of HIV-1 TAR RNA by a D-Tat peptide

✍ Scribed by Huq, Ikramul ;Wang, Xilu ;Rana, Tariq M.


Book ID
109965298
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
246 KB
Volume
4
Category
Article
ISSN
1545-9993

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Interference of binding of Tat protein to TAR RNA in HIV-1-infected cells may be a useful therapeutic strategy for AIDS. An electrophoretic assay to screen potential low-molecular-weight (< 2 kDa) Tat antagonists has been established. A radiolabeled TAR RNA fragment (delta TAR) is retarded in mobili