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Specific polypeptide markers in chronic B cell malignancies detected by two-dimensional gel electrophoresis

✍ Scribed by Simin Talebian-Ziai; Zahia Azgui; Françoise Valensi; François Sigaux; Prof. Dominique Charron


Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
700 KB
Volume
13
Category
Article
ISSN
0173-0835

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B-chronic lymphocytic leukemia (CLL) is characterized by an accumulation of long-lived, resting B cells expressing the Bcl-2 protein. However, less than 10% of the CLL patients shows bcl-2 gene rearrangement in blood cells, using traditional Southern blotting analysis. In the present study, rearrang