Patterns of DNA migration in two-dimensional single-cell gel electrophoresis analyzed by DNA breakage detection-fluorescence in situ hybridization

Evaluation of the genotoxic activity of

Evaluation of the genotoxic activity of paclitaxel by the in vitro micronucleus test in combination with fluorescent in situ hybridization of a DNA centromeric probe and the alkaline single cell gel electrophoresis technique (comet assay) in human T-lymphocytes

✍ L. Digue; T. Orsière; M. De Méo; M. G. Mattéi; D. Depetris; F. Duffaud; R. Favre 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 112 KB 👁 3 views

Paclitaxel is a recent chemotherapeutic agent that inhibits tubulin depolymerization in tumoral cells. Despite its increasing use against various human cancers, the genotoxicity of paclitaxel has never been studied on normal human cells. The in vitro genotoxic effects of the drug were evaluated with