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Specific Lymphocyte Subsets Predict Response to Adoptive Cell Therapy Using Expanded Autologous Tumor-Infiltrating Lymphocytes in Metastatic Melanoma Patients

✍ Scribed by Radvanyi, L. G.; Bernatchez, C.; Zhang, M.; Fox, P. S.; Miller, P.; Chacon, J.; Wu, R.; Lizee, G.; Mahoney, S.; Alvarado, G.; Glass, M.; Johnson, V. E.; McMannis, J. D.; Shpall, E.; Prieto, V.; Papadopoulos, N.; Kim, K.; Homsi, J.; Bedikian, A.; Hwu, W.-J.; Patel, S.; Ross, M. I.; Lee, J. E.; Gershenwald, J. E.; Lucci, A.; Royal, R.; Cormier, J. N.; Davies, M. A.; Mansaray, R.; Fulbright, O. J.; Toth, C.; Ramachandran, R.; Wardell, S.; Gonzalez, A.; Hwu, P.

Book ID
125974421
Publisher
American Association for Cancer Research
Year
2012
Tongue
English
Weight
787 KB
Volume
18
Category
Article
ISSN
1078-0432

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Human autologous tumor-specific T-helper 2 (Th2) cells were investigated in melanoma tumor-infiltrating lymphocytes FILS). Both a CD4+ T-cell line and its 5 potential T-cell clones established from TlLs of a patient with metastatic melanoma produced significant levels of IL-4, IL-6, IL-10 and granul