The monoclonal antibody (MAb) K1 is a murine IgG 1 that recognizes mesothelin, a differentiation antigen present on mesothelium which is highly expressed on cancers derived from mesothelium, including most ovarian cancers and epithelioid mesotheliomas. MAb K1 was conjugated to 2-(pisothiocyanatobenz
✦ LIBER ✦
Specific localization of In-111-labeled monoclonal antibody versus 67-Ga-labeled immunoglobulin in mice bearing human breast carcinoma xenografts
✍ Scribed by H. Haisma; W. Goedemans; M. Jong; J. Hilkens; J. Hilgers; H. Dullens; W. Otter
- Publisher
- Springer-Verlag
- Year
- 1984
- Tongue
- English
- Weight
- 539 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0340-7004
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## Abstract Carbonic anhydrase IX (CA IX) is frequently expressed in human carcinomas and absent from the corresponding normal tissues. Strong induction by tumor hypoxia predisposes CA IX to serve as a target for cancer diagnostics and therapy. Here we evaluated targeting properties and pharmacokin