Distribution of 111in- and 125i-labeled monoclonal antibody 17-1a in mice bearing xenografts of human pancreatic carcinoma hup-t4

Biodistribution and pharmacokinetics of

Biodistribution and pharmacokinetics of 125I-labeled monoclonal antibody M75 specific for carbonic anhydrase IX, an intrinsic marker of hypoxia, in nude mice xenografted with human colorectal carcinoma

✍ Adrián Chrastina; Jan Závada; Seppo Parkkila; Štefan Kaluz; Milota Kaluzová; Júl 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 417 KB

## Abstract Carbonic anhydrase IX (CA IX) is frequently expressed in human carcinomas and absent from the corresponding normal tissues. Strong induction by tumor hypoxia predisposes CA IX to serve as a target for cancer diagnostics and therapy. Here we evaluated targeting properties and pharmacokin