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Specific inhibition of K-ras expression and tumorigenicity of lung cancer cells by antisense RNA


Book ID
123235060
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
162 KB
Volume
7
Category
Article
ISSN
0169-5002

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The lung carcinoma cell line Calu3, which overexpresses the c-erbB-2 oncogene, was stably transfected with antisense (AS) cDNA constructs encompassing different regions of the c-erbB-2 gene. Transfected cells were analyzed for their tumorigenic properties in vitro and in nude mice. Two independent c