4-Benzylaminoquinazolines can be potent reversible inhibitors of the EGFR tyrosine kinase at the ATP binding site. Examination of benzylic methylation reveals that an (R)-methyl group is four- to six-fold activating, with an optimal Ki of 630 pM for compound 11. In sharp contrast, (S)-methylation ca
โฆ LIBER โฆ
Specific inhibition of epidermal growth factor receptor tyrosine kinase by 4-anilinoquinazolines
โ Scribed by A. E. Wakeling; A. J. Barker; D. H. Davies; D. S. Brown; L. R. Green; S. A. Cartlidge; J. R. Woodburn
- Publisher
- Springer US
- Year
- 1996
- Tongue
- English
- Weight
- 506 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0167-6806
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