๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Specific inhibition of epidermal growth factor receptor tyrosine kinase by 4-anilinoquinazolines

โœ Scribed by A. E. Wakeling; A. J. Barker; D. H. Davies; D. S. Brown; L. R. Green; S. A. Cartlidge; J. R. Woodburn


Publisher
Springer US
Year
1996
Tongue
English
Weight
506 KB
Volume
38
Category
Article
ISSN
0167-6806

No coin nor oath required. For personal study only.


๐Ÿ“œ SIMILAR VOLUMES


Enantioselective inhibition of the epide
โœ Alexander J. Bridges; Donna R. Cody; Hairong Zhou; Amy McMichael; David W. Fry ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 523 KB

4-Benzylaminoquinazolines can be potent reversible inhibitors of the EGFR tyrosine kinase at the ATP binding site. Examination of benzylic methylation reveals that an (R)-methyl group is four- to six-fold activating, with an optimal Ki of 630 pM for compound 11. In sharp contrast, (S)-methylation ca

Ratiometric Assay of Epidermal Growth Fa
โœ Kevin Schooler; H.Steven Wiley ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 148 KB

Activation of cells is frequently followed by tyrosine phosphorylation of proteins. To quantify this process, we developed a ratiometric enzyme-linked immunosorbent assay (ELISA) using epidermal growth factor receptors (EGFR) as a model. Microtiter dishes were coated with anti-EGFR monoclonal antibo