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1,4-Dioxane-fused 4-anilinoquinazoline as inhibitors of epidermal growth factor receptor kinase

✍ Scribed by Jae Yeol Lee; Yong Kyu Park; Seon Hee Seo; In-Seop So; Hee-Kyung Chung; Beom-Seok Yang; Sook Ja Lee; Hokoon Park; Yong Sup Lee


Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
43 KB
Volume
334
Category
Article
ISSN
0365-6233

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7-Substituted-[1, 4]dioxano[2, 3-g]quina
✍ Jae Yeol Lee; Yong Kyu Park; Seon Hee Seo; Beom-Seok Yang; Hokoon Park; Yong Sup πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 123 KB

## Abstract With the aim of developing inhibitors of EGFR tyrosine kinase, the 7‐methoxymethyl‐[1, 4]dioxano[2, 3‐__g__]quinazolines (**3aβ€”b**) and 7‐mono‐ or di‐alkylaminomethyl‐[1, 4]dioxano[2, 3‐__g__]quinazolines (**4aβ€”i**) were prepared and evaluated for the inhibition of EGFR tyrosine kinase