Specific inhibition of cyclin-dependent kinase 5 activity induces motor neuron development in vivo
β Scribed by Jyotshnabala Kanungo; Ya-Li Zheng; Niranjana D. Amin; Sukhbir Kaur; Ramani Ramchandran; Harish C. Pant
- Book ID
- 116298775
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 552 KB
- Volume
- 386
- Category
- Article
- ISSN
- 0006-291X
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Cyclin-dependent kinase 5 (Cdk5) is a member of the cyclin-dependent kinase family that is involved in the regulation of the cell cycle. As their name suggests, the Cdks require association with activator proteins called cyclins for their activity. Cdk5, however, is unique to this family of proline-
## Abstract Roscovitine, a cyclinβdependent kinase (Cdk) inhibitor, inhibited kinase activity and the axenic growth of __Dictyostelium discoideum__ at micromolar concentrations. Growth was almost fully rescued in 50βΒ΅M and βΌ50% rescued in 100βΒ΅M roscovitineβtreated cultures by the overβexpression o