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Inhibition of Melatonin Biosynthesis Induces Neurofilament Hyperphosphorylation with Activation of Cyclin-dependent Kinase 5

✍ Scribed by Shaohui Wang; Lingqiang Zhu; Hairong Shi; Hongyun Zheng; Qing Tian; Qun Wang; Rong Liu; Jian-Zhi Wang


Book ID
106483660
Publisher
Springer
Year
2007
Tongue
English
Weight
359 KB
Volume
32
Category
Article
ISSN
0364-3190

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Cyclin-dependent kinase 5 (cdk5) activat
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## Abstract Cyclin‐dependent kinase 5 (cdk5), in contrast to other members of the cyclin‐dependent kinase family, is not activated by cyclins but instead is activated by complexing with neuron‐specific activator molecules (p35, p39, and p67). The most effective activator of cdk5 both in vitro and i