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Specific gene expression and therapy for pancreatic cancer using the cytosine deaminase gene directed by the rat insulin promoter

✍ Scribed by Wang, Xiao-Ping; Yazawa, Kazuyuki; Fisher, William; Brunicardi, Charles


Book ID
123516260
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
177 KB
Volume
124
Category
Article
ISSN
0016-5085

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## Abstract ## Background Cytosine deaminase (CD) activates prodrug 5‐FC to 5‐FU and is used for suicide gene therapy (the CD/5‐FC system). __E. coli__ uracil phosphoribosyltransferase (UPRT) is a pyrimidine salvage enzyme that directly converts 5‐FU into 5‐fluorouridine monophosphate and improves