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In vivo gene therapy for colon cancer using adenovirus-mediated, transfer of the fusion gene cytosine deaminase and uracil phosphoribosyltransferase

✍ Scribed by Chung-Faye, G A; Chen, M J; Green, N K; Burton, A; Anderson, D; Mautner, V; Searle, P F; Kerr, D J

Book ID: 110039013
Publisher: Nature Publishing Group
Year: 2001
Tongue: English
Weight: 165 KB
Volume: 8
Category: Article
ISSN: 0969-7128
DOI: 10.1038/sj.gt.3301557

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## Abstract ## Background Cytosine deaminase (CD) activates prodrug 5‐FC to 5‐FU and is used for suicide gene therapy (the CD/5‐FC system). __E. coli__ uracil phosphoribosyltransferase (UPRT) is a pyrimidine salvage enzyme that directly converts 5‐FU into 5‐fluorouridine monophosphate and improves