CSF-1 is a hemopoietic growth factor that specifically regulates the survival, proliferation, and differentiation of mononuclear phagocytic cells. Populations of adherent bone marrow-derived macrophages (BMM) devoid of CSF-1 producing cells were used to study regulation by CSF-1 of macrophage entry
Specific Binding of the Mononuclear Phagocyte Colony-Stimulating Factor CSF-1 to the Product of the v-fms Oncogene
โ Scribed by Rosalba Sacca, E. Richard Stanley, Charles J. Sherr and Carl W. Rettenmier
- Book ID
- 123632836
- Publisher
- National Academy of Sciences
- Year
- 1986
- Tongue
- English
- Weight
- 921 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0027-8424
- DOI
- 10.2307/27496
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The product of the c --proto-oncogene is related to, and possibly identical with, the receptor for the macrophage colony-stimulating factor, M-CSF (CSF-1). Unlike the product of the v-erbB oncogene, which is a truncated version of the EGF receptor, the glycoprotein encoded by the v-@ oncogene retain
Colony stimulating factor-1 (CSF-1) is the primary regulator of the mononuclear phagocytic lineage acting through its transmembrane tyrosine kinase receptor, CSF-1R, that is the product of the c-fms proto-oncogene. Null mutations in either the ligand or the receptor genes result in a severe osteopet