Specific antagonism by dopamine inhibitors of items of amphetamine induced aggressive behaviour

✍ Scribed by E. Hasselager; Z. Rolinski; A. Randrup

• Book ID: 104769634
• Publisher: Springer
• Year: 1972
• Tongue: English
• Weight: 535 KB
• Volume: 24
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00423439

✦ Synopsis

d-Amphetamine in a dose of 15 mg/kg elicits both aggressive activities and stereotyped sniffing, licking and biting of the cage in mice. A selective inhibition of the aggressive activities (without general sedation of the mice) was obtained by small doses of the neuroleptics spiramide and trifluperazine, indicating that this behaviour was mediated by increased activity of dopamine in the brain. This indication was supported by experiments with noradrenaline blocking agents and inhibitors of the synthesis of dopamine and noradrenaline.