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Antagonism of AP-5- and amphetamine-induced behaviour by timelotem as compared with clozapine and haloperidol

✍ Scribed by W.J. Schmidt; H. Krähling; M. Ruhland


Book ID
118342773
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
323 KB
Volume
41
Category
Article
ISSN
0024-3205

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DL-2-amino-5-phosphonovaleric acid (AP-5), which blocks glutamatergic transmission at the NMDA-preferring receptor, was injected into the antero-dorsal striatum of rats. AP-5-induced behavioural changes were assessed i) using a stereotypy rating scale and ii) using an experimental chamber designed t