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Specific analysis of KIT and PDGFR-alpha expression and mutational status in Merkel cell carcinoma

✍ Scribed by Swick, Brian L.; Srikantha, Rupasree; Messingham, Kelly N.


Book ID
120445846
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
751 KB
Volume
40
Category
Article
ISSN
0303-6987

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## Abstract Most Merkel cell carcinomas (MCCs) contain Merkel cell polyomavirus (MCPyV) DNA, and the virus likely has a pivotal role in tumor pathogenesis. p53 and the KIT receptor tyrosine kinase have also been implicated in MCC pathogenesis, but little is known about their association with MCPyV