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598 Association of Merkel cell polyomavirus infection with p53, KIT, PDGFR-alpha, stem cell factor and survival in Merkel cell carcinoma

✍ Scribed by M. Waltari; H. Sihto; H. Kukko; V. Koljonen; R. Sankila; T. Böhling; H. Joensuu

Book ID
119603281
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
45 KB
Volume
8
Category
Article
ISSN
1359-6349

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Association of Merkel cell polyomavirus
Association of Merkel cell polyomavirus infection with tumor p53, KIT, stem cell factor, PDGFR-alpha and survival in Merkel cell carcinoma
✍ Marika Waltari; Harri Sihto; Heli Kukko; Virve Koljonen; Risto Sankila; Tom Böhl 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 French ⚖ 709 KB

## Abstract Most Merkel cell carcinomas (MCCs) contain Merkel cell polyomavirus (MCPyV) DNA, and the virus likely has a pivotal role in tumor pathogenesis. p53 and the KIT receptor tyrosine kinase have also been implicated in MCC pathogenesis, but little is known about their association with MCPyV

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## Abstract The co‐expression of KIT receptor and its ligand stem cell factor (SCF) has been reported in biopsy specimens of Merkel cell carcinoma (MCC). However, the functional role of SCF/KIT in the pathogenesis of this aggressive tumor has not been elucidated. The present study reports expressio