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Species differences of the stereoselective binding of phenprocoumon and warfarin enantiomers to serum albumins

✍ Scribed by Brown, Nigel A.; Jähnchen, Eberhard; Müller, Walter E.; Schmidt, Willy; Wollert, Uwe


Book ID
122661319
Publisher
Elsevier Science
Year
1979
Weight
402 KB
Volume
62
Category
Article
ISSN
0306-4492

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Binding of ibuprofen (IB) enantiomers to human serum albumin (HSA) was studied using a chiral fluorescent derivatizing reagent, which enabled the measurement of IB enantiomers at a concentration as low 5 x 10(-8) M. Scatchard analyses revealed that there were two classes of binding sites for both en