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Species differences in the generation of the chiral sulfoxide metabolite of albendazole in sheep and rats

✍ Scribed by P. Delatour; E. Benoit; M. Caude; A. Tambute

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
368 KB
Volume
2
Category
Article
ISSN
0899-0042

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✦ Synopsis

Abstract

The prochiral anthelmintic drug albendazole was administered orally to sheep and rats. Blood samples were taken at standardized intervals during the time course of the plasma kinetics: 18 h in rats and 48 h in sheep. The enantiomeric ratio of the sulfoxide metabolite was determined by means of HPLC on a chiral stationary phase, the chiral selector of which was a N‐3,5‐dinitrobenzoyl derivative of (S)‐tyrosine. Two enantiomers were detected in both animal species but their ratios were inverted in rat vs. sheep. The evolution of the ratio is turned from a racemate at 15 min to 60(βˆ’):40(+) at 12 h in rats, while it moved from 23(βˆ’):77(+) at 3 h to 4(βˆ’):96(+) at 36 h after administration in sheep.

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