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Enantioselective analysis of albendazole sulfoxide in plasma using the chiral stationary phase

✍ Scribed by Fernanda Orsi Paias; Vera Lúcia Lanchote; Osvaldo Massaiti Takayanagui; Pierina Sueli Bonato

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
68 KB
Volume
9
Category
Article
ISSN
0899-0042

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✦ Synopsis

We present a method for the enantioselective analysis of albendazole sulfoxide (ABZSO) in plasma for application in clinical pharmacokinetic studies. ABZSO enantiomers were separated on a 5-micron Chiralcel OB-H column (4.6 x 150 mm) using hexane:ethanol (93:7, v/v) as the mobile phase and fluorescence detection. ABZSO was extracted with chloroform:isopropanol (8:2, v/v) from 500-microliter aliquots of acidified plasma, with full drug recovery. The proposed method presented quantitation limits of 20 ng/ml for (-)ABZSO and 50 ng/ml for (+)ABZSO and was linear up to a concentration of 5,000 ng/ml of each enantiomer.

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