Species Difference among Experimental Rodents in Induction of P450IA Family Enzymes by 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
โ Scribed by Degawa, Masakuni ;Kobayashi, Ken-ichiro ;Miura, Shin-ichi ;Arai, Hiroshi ;Esumi, Hiroyasu ;Sugimura, Takashi ;Hashimoto, Yoshiyuki
- Book ID
- 108579558
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1992
- Tongue
- English
- Weight
- 505 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0910-5050
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## Abstract 2โAminoโ1โmethylโ6โphenylimidazo[4,5โ__b__]pyridine(PhlP) is the most abundant of the heterocyclic amines, a group of potent carcinogens contained in cooked meat and fish. Female F344 rats fed a diet containing 100 or 400 ppm PhIP developed mammary carcinomas within 104 or 52 wk, respec
## Abstract 2โAminoโ1โmethylโ6โphenylimidazo[4,5โ__b__]pyridine (PhIP) is the most abundant mutagenic heterocyclic amine in cooked foods. Two mouse tumor cell lines, BMT11 and FM3A, were exposed to its proximate form, 2โhydroxyaminoโ1โmethylโ6โphenylimidazo[4,5โ__b__]pyridine (__N__โOHโPhIP). Fifty